Compound research
NAD+ (Nicotinamide Adenine Dinucleotide) Precursors: Research Overview & Current Status
NAD+ (Nicotinamide Adenine Dinucleotide) Precursors is a Metabolic coenzyme / coenzyme precursor (not a peptide; small-molecule NAD+ biosynthesis intermediates). Current research status: in clinical trials. NMN and NR are studied as dietary-supplement-category compounds with an active human clinical trial base, but neither has FDA approval as a drug for any indication; the FDA has taken the position that NMN does not qualify as a lawful dietary supplement ingredient in some contexts due to prior investigational new drug (IND) status, a matter that has seen ongoing regulatory back-and-forth.
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Peptide Giants
Tracked$32.99 / 100mg($32.99 to 10mg)
Checked Aug 1, 2026
Check price at Peptide Giants →Anglo Peptides
Tracked$34.96 / 500mg($34.96 to 10mg)
Checked Jul 19, 2026
Check price at Anglo Peptides →TrustedPeps
Tracked$35.00 / 500mg($35.00 to 10mg)
Checked Aug 1, 2026
Check price at TrustedPeps →Euno Labs Research
Tracked$35.99 / 100mg($35.99 to 10mg)
Checked Jul 25, 2026
Check price at Euno Labs Research →Peptides For Less
Tracked$36.00 / 100mg($36.00 to 10mg)
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Check price at Peptides For Less →Badger Compounds
Tracked$36.99 / 500mg($36.99 to 10mg)
Checked Aug 15, 2026
Check price at Badger Compounds →Noble Sciences
Tracked$39.00 / 500mg($39.00 to 10mg)
Checked Aug 1, 2026
Check price at Noble Sciences →IDUN Peptides
Tracked$39.99 / 500mg($39.99 to 10mg)
Checked Jul 17, 2026
Check price at IDUN Peptides →Axiom Peptides
Tracked$40.00 / 500mg($40.00 to 10mg)
Checked Apr 14, 2026
Check price at Axiom Peptides →CertaPeptides
Tracked$41.00 / 100mg($41.00 to 10mg)
Checked Jun 27, 2026
Check price at CertaPeptides →Puratek Peptides
Tracked$42.95 / 500mg($42.95 to 10mg)
Checked Jul 31, 2026
Check price at Puratek Peptides →Everest Peptides
Tracked$44.99 / 500mg($44.99 to 10mg)
Checked Jul 28, 2026
Check price at Everest Peptides →PeptiNova
Tracked$44.99 / 500mg($44.99 to 10mg)
Checked Aug 13, 2026
Check price at PeptiNova →RemedyX Labs
Tracked$45.00 / 500mg($45.00 to 10mg)
Checked Aug 1, 2026
Check price at RemedyX Labs →$47.00 / 100mg($47.00 to 10mg)
Checked Apr 16, 2026
Check price at Core Peptides →Endura Peptides
Tracked$48.00 / 500mg($48.00 to 10mg)
Checked Aug 3, 2026
Check price at Endura Peptides →Optima Supply
Tracked$49.99 / 500mg($49.99 to 10mg)
Checked Aug 3, 2026
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Tracked$49.99 / 500mg($49.99 to 10mg)
Checked Aug 2, 2026
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Tracked$49.99 / 500mg($49.99 to 10mg)
Checked Aug 3, 2026
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Tracked$50.00 / 500mg($50.00 to 10mg)
Checked Jun 5, 2026
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Tracked$50.00 / 500mg($50.00 to 10mg)
Checked Jul 24, 2026
Check price at NextGen Peptides →Nationwide Peptides
Tracked$53.00 / 100mg($53.00 to 10mg)
Checked Aug 5, 2026
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Tracked$54.99 / 500mg($54.99 to 10mg)
Checked May 14, 2026
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Tracked$54.99 / 500mg($54.99 to 10mg)
Checked Jul 30, 2026
Check price at VoidResearch →Axon Chems
Tracked$55.00 / 500mg($55.00 to 10mg)
Checked Jul 31, 2026
Check price at Axon Chems →Elytra Labs
Tracked$55.00 / 1000mg($55.00 to 10mg)
Checked Aug 2, 2026
Check price at Elytra Labs →Peptides For Less
Tracked$55.00 / 500mg($55.00 to 10mg)
Checked Aug 13, 2026
Check price at Peptides For Less →Glacier Aminos
Tracked$56.99 / 500mg($56.99 to 10mg)
Checked Jul 31, 2026
Check price at Glacier Aminos →$58.00 / 500mg($58.00 to 10mg)
Checked Apr 16, 2026
Check price at Ascension Peptides →Elite Edge Biotech
Tracked$58.00 / 500mg($58.00 to 10mg)
Checked Jul 28, 2026
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Tracked$58.99 / 500mg($58.99 to 10mg)
Checked Apr 6, 2026
Check price at Olympex Solutions →Nationwide Peptides
Tracked$59.00 / 500mg($59.00 to 10mg)
Checked Aug 5, 2026
Check price at Nationwide Peptides →PeakForce Labs
Tracked$59.00 / 500mg($59.00 to 10mg)
Checked Aug 15, 2026
Check price at PeakForce Labs →NeuroLabs
Tracked$59.95 / 500mg($59.95 to 10mg)
Checked Jul 31, 2026
Check price at NeuroLabs →Midwest Peptide
Tracked$59.99 / 500mg($59.99 to 10mg)
Checked Jun 18, 2026
Check price at Midwest Peptide →Mile High Compounds
Tracked$59.99 / 500mg($59.99 to 10mg)
Checked Aug 3, 2026
Check price at Mile High Compounds →Premier Research
Tracked$60.00 / 500mg($60.00 to 10mg)
Checked Jul 20, 2026
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Tracked$60.00 / 500mg($60.00 to 10mg)
Checked Jul 28, 2026
Check price at Offline Peptides →Refined BioLabs
Tracked$60.00 / 500mg($60.00 to 10mg)
Checked Jul 30, 2026
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Tracked$60.00 / 500mg($60.00 to 10mg)
Checked Aug 8, 2026
Check price at Cielo Peptides →Global Aminos
Tracked$61.99 / 500mg($61.99 to 10mg)
Checked Jul 28, 2026
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Tracked$62.99 / 1000mg($62.99 to 10mg)
Checked Aug 15, 2026
Check price at Badger Compounds →Chameleon Peptides
Tracked$63.00 / 500mg($63.00 to 10mg)
Checked Jul 31, 2026
Check price at Chameleon Peptides →Peptide Giants
Tracked$63.79 / 500mg($63.79 to 10mg)
Checked Aug 1, 2026
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Tracked$64.99 / 500mg($64.99 to 10mg)
Checked Aug 15, 2026
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Tracked$65.00 / 500mg($65.00 to 10mg)
Checked Jun 19, 2026
Check price at GLP-1 Research Lab →True Research Labs
Tracked$69.00 / 500mg($69.00 to 10mg)
Checked Aug 15, 2026
Check price at True Research Labs →Apex Peptides Lab
Tracked$69.00 / 500mg($69.00 to 10mg)
Checked Aug 15, 2026
Check price at Apex Peptides Lab →Amino Club
Tracked$69.99 / 500mg($69.99 to 10mg)
Checked Aug 7, 2026
Check price at Amino Club →Novatherix Laboratories
Tracked$69.99 / 500mg($69.99 to 10mg)
Checked Jun 4, 2026
Check price at Novatherix Laboratories →Arizen Bio Labs
Tracked$69.99 / 500mg($69.99 to 10mg)
Checked Jun 21, 2026
Check price at Arizen Bio Labs →Evo Labs Research
Tracked$69.99 / 500mg($69.99 to 10mg)
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Check price at Evo Labs Research →Woosh Labs
Tracked$69.99 / 500mg($69.99 to 10mg)
Checked Jun 24, 2026
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Tracked$69.99 / 500mg($69.99 to 10mg)
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Tracked$69.99 / 500mg($69.99 to 10mg)
Checked Jul 29, 2026
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Tracked$69.99 / 500mg($69.99 to 10mg)
Checked Aug 2, 2026
Check price at Eternal Peptides →Pure Amino
Tracked$69.99 / 500mg($69.99 to 10mg)
Checked Aug 15, 2026
Check price at Pure Amino →CertaPeptides
Tracked$74.04 / 250mg($74.04 to 10mg)
Checked Jun 27, 2026
Check price at CertaPeptides →LA Peptides
Tracked$74.99 / 500mg($74.99 to 10mg)
Checked May 14, 2026
Check price at LA Peptides →Apex Peptide Supply
Tracked$74.99 / 500mg($74.99 to 10mg)
Checked May 14, 2026
Check price at Apex Peptide Supply →Ascending Labs
Tracked$75.00 / 1000mg($75.00 to 10mg)
Checked Jul 25, 2026
Check price at Ascending Labs →Pantheon Peptides
Tracked$77.76 / 500mg($77.76 to 10mg)
Checked Apr 23, 2026
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Tracked$77.99 / 500mg($77.99 to 10mg)
Checked Jul 23, 2026
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Tracked$82.03 / 500mg($82.03 to 10mg)
Checked Aug 7, 2026
Check price at Durham Peptides →Onyx Research
Tracked$85.00 / 500mg($85.00 to 10mg)
Checked Apr 6, 2026
Check price at Onyx Research →Axon Chems
Tracked$90.00 / 1000mg($90.00 to 10mg)
Checked Jul 31, 2026
Check price at Axon Chems →Elite Edge Biotech
Tracked$90.00 / 1000mg($90.00 to 10mg)
Checked Jul 28, 2026
Check price at Elite Edge Biotech →Polar Peptides
Tracked$93.59 / 500mg($93.59 to 10mg)
Checked Apr 17, 2026
Check price at Polar Peptides →Pristine Aminos
Tracked$95.00 / 500mg($95.00 to 10mg)
Checked Aug 2, 2026
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Tracked$98.00 / 500mg($98.00 to 10mg)
Checked Jul 20, 2026
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Tracked$98.10 / 1000mg($98.10 to 10mg)
Checked Jul 31, 2026
Check price at Chameleon Peptides →Peptide Giants
Tracked$98.99 / 1000mg($98.99 to 10mg)
Checked Aug 1, 2026
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Tracked$99.00 / 1000mg($99.00 to 10mg)
Checked Jun 5, 2026
Check price at Hydro Research →Optima Supply
Tracked$99.00 / 1000mg($99.00 to 10mg)
Checked Aug 3, 2026
Check price at Optima Supply →Arizen Bio Labs
Tracked$99.99 / 1000mg($99.99 to 10mg)
Checked Jun 21, 2026
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Tracked$99.99 / 1000mg($99.99 to 10mg)
Checked Jun 22, 2026
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Tracked$99.99 / 1000mg($99.99 to 10mg)
Checked Jul 16, 2026
Check price at Averix Labs →Ignite Peptides
Tracked$100.00 / 500mg($100.00 to 10mg)
Checked Jun 12, 2026
Check price at Ignite Peptides →Premier Research
Tracked$100.00 / 1000mg($100.00 to 10mg)
Checked Jul 20, 2026
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Tracked$100.00 / 1000mg($100.00 to 10mg)
Checked Aug 13, 2026
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Tracked$100.79 / 600mg($100.79 to 10mg)
Checked Apr 17, 2026
Check price at Polar Peptides →$103.00 / 250mg($103.00 to 10mg)
Checked Apr 16, 2026
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Tracked$109.99 / 500mg($109.99 to 10mg)
Checked Aug 6, 2026
Check price at Swift Peptides →CertaPeptides
Tracked$116.19 / 500mg($116.19 to 10mg)
Checked Jun 27, 2026
Check price at CertaPeptides →Durham Peptides
Tracked$117.70 / 1000mg($117.70 to 10mg)
Checked Aug 7, 2026
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Tracked$119.99 / 1000mg($119.99 to 10mg)
Checked May 14, 2026
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Tracked$119.99 / 1000mg($119.99 to 10mg)
Checked Jul 23, 2026
Check price at SKO Compounds →Liv Pure Wellness
Tracked$120.00 / 500mg($120.00 to 10mg)
Checked Apr 14, 2026
Check price at Liv Pure Wellness →Evolve Peptides
Tracked$125.00 / 500mg($125.00 to 10mg)
Checked Apr 22, 2026
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Tracked$129.00 / 1000mg($129.00 to 10mg)
Checked Aug 15, 2026
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Tracked$129.99 / 500mg($129.99 to 10mg)
Checked Jun 4, 2026
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Tracked$132.00 / 1000mg($132.00 to 10mg)
Checked Aug 5, 2026
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Tracked$135.00 / 500mg($135.00 to 10mg)
Checked Apr 6, 2026
Check price at LeoLab Rx →Polar Peptides
Tracked$143.99 / 1000mg($143.99 to 10mg)
Checked Apr 17, 2026
Check price at Polar Peptides →Dynotides
Tracked$148.00 / 1000mg($148.00 to 10mg)
Checked Jul 20, 2026
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Checked Apr 16, 2026
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Tracked$153.99 / 1000mg($153.99 to 10mg)
Checked Aug 6, 2026
Check price at Swift Peptides →Pristine Aminos
Tracked$175.00 / 1000mg($175.00 to 10mg)
Checked Aug 2, 2026
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Tracked$180.00 / 500mg($180.00 to 10mg)
Checked Aug 7, 2026
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Checked Jun 27, 2026
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Tracked$198.00 / 500mg($198.00 to 10mg)
Checked Aug 5, 2026
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Tracked$199.00 / 1000mg($199.00 to 10mg)
Checked Apr 14, 2026
Check price at Liv Pure Wellness →Evolve Peptides
Tracked$200.00 / 1000mg($200.00 to 10mg)
Checked Apr 22, 2026
Check price at Evolve Peptides →$207.00 / 1000mg($207.00 to 10mg)
Checked Jul 31, 2026
Check price at Amino Vault →BioLongevity Labs
Tracked$249.97 / 500mg($249.97 to 10mg)
Checked Aug 2, 2026
Check price at BioLongevity Labs →$292.00 / 750mg($292.00 to 10mg)
Checked Apr 16, 2026
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Tracked$340.00 / 5000mg($340.00 to 10mg)
Checked Jul 24, 2026
Check price at NextGen Peptides →Alpha Peptides
Tracked$30.52 / 500mg($30.52 to 10mg)
Checked Jul 31, 2026
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Tracked$59.99 / 500mg($59.99 to 10mg)
Checked Jul 16, 2026
Check price at Averix Labs →Purgo Labs
Tracked$59.99 / 500mg($59.99 to 10mg)
Checked Aug 1, 2026
Check price at Purgo Labs →Puratek Peptides
Tracked$68.95 / 1000mg($68.95 to 10mg)
Checked Jul 31, 2026
Check price at Puratek Peptides →Purgo Labs
Tracked$69.99 / 1000mg($69.99 to 10mg)
Checked Aug 1, 2026
Check price at Purgo Labs →Purity Peptides
Tracked$90.09 / 500mg($90.09 to 10mg)
Checked Jul 16, 2026
Check price at Purity Peptides →Peptime
Tracked$99.00 / 1000mg($99.00 to 10mg)
Checked Jul 25, 2026
Check price at Peptime →NAD+ (Nicotinamide Adenine Dinucleotide) Precursors price report
NAD+ (Nicotinamide Adenine Dinucleotide) Precursors currently costs as little as $30.52 to obtain 10mg, from Alpha Peptides. Across the 85 vendors we track, the typical cost to 10mg is $60.00, using each vendor's own cheapest listing. 81 of those vendors show current stock, and prices were checked through Aug 15, 2026.
- Lowest to 10mg
- $30.52
- Alpha Peptides
- Median to 10mg
- $60.00
- one offer per vendor
- Lowest package
- $32.99
- 100mg at Peptide Giants
- Vendors tracked
- 85
- 81 in stock
Checked through Aug 15, 2026. Prices are aggregated from public vendor listings. Sources and data licensing are documented on our methodology page.
At a glance
- Category
- recovery
- Mechanism class
- Other research peptide
- Research phase
- Research / preclinical only
- NCAA status
- Permitted — Nicotinamide adenine dinucleotide. Not on NCAA or WADA prohibited list.
- WADA status
- Prohibited (WADA S2 — Peptide Hormones, Growth Factors, Related Substances)
Overview
NAD+ is an essential coenzyme involved in cellular energy metabolism and redox reactions, with levels known to decline with age. Research in this space centers on precursor molecules, primarily nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), that are metabolized into NAD+, rather than on NAD+ itself, which is not efficiently absorbed intact.
Metabolic coenzyme / coenzyme precursor (not a peptide; small-molecule NAD+ biosynthesis intermediates)
Research timeline
2010s
Animal studies established that NAD+ levels decline with aging and that boosting NAD+ via NMN or NR supplementation can increase health parameters and lifespan in aging animal models.
Source →2023
Preclinical stable-isotope tracing study reported that exogenous NMN is primarily converted to nicotinamide and then to NR before being used for NAD+ synthesis, suggesting NR may be a more direct/efficient precursor.
Source →2024
FASEB Scientific Research Conference on NAD Metabolism and Signaling highlighted growing 'bench to clinic' research interest and individual variability in response to NAD+ precursors.
Source →2025
Systematic review and meta-analysis on skeletal muscle mass/function found NMN/NR research promising for age-related sarcopenia but evidence in older adults remains inconclusive.
Source →2025
Geromedicine-focused systematic review of RCTs (2020-2025) compiled completed trials of NAD+ precursors in Alzheimer's disease, mild cognitive impairment, Parkinson's disease, and peripheral artery disease.
Source →2025-2026
Head-to-head human trial published in Nature Metabolism directly compared NMN, NR, and nicotinamide (Nam), finding NMN and NR each approximately doubled circulating NAD+ over 14 days while Nam did not sustain the increase; gut bacteria conversion to nicotinic acid (NA) was implicated as a mechanism.
Source →
Active & recent research
Head-to-head human comparison of NMN, NR, and nicotinamide
Direct comparison of circulating NAD+ increases among three precursor forms and the role of gut microbiome conversion
NMN/NR effects on skeletal muscle mass and function
Evaluating evidence for NAD+ precursor supplementation on age-related sarcopenia; found inconclusive in older adults
NAD+ precursors in neurodegenerative and vascular disease
Compiling completed clinical trials of NAD+ precursors in Alzheimer's disease, MCI, Parkinson's disease, and peripheral artery disease
Key findings
- A recent head-to-head human trial (Nature Metabolism) reported that both NMN and NR approximately doubled circulating NAD+ levels after 14 days of supplementation, while nicotinamide alone produced only a transient increase.
- That trial identified gut bacterial conversion of NMN and NR into nicotinic acid (NA) as a proposed mechanism for raising circulating NAD+, adding nuance to earlier assumptions about direct cellular uptake.
- A 2025 systematic review and meta-analysis on skeletal muscle outcomes concluded that while NMN/NR are of interest for age-related sarcopenia, current evidence in older adults remains inconclusive and requires larger, longer trials.
- A 2023 preclinical stable-isotope tracing study suggested NMN must first be converted to nicotinamide and then NR before contributing meaningfully to NAD+ synthesis, an important caveat for interpreting comparative efficacy claims between the two precursor forms.
Safety & regulatory notes
NMN and NR are marketed as dietary supplements in some jurisdictions rather than as approved drugs; neither has FDA approval for treating any disease. The FDA has at various points taken the position that NMN's earlier investigational new drug (IND) status may preclude its lawful marketing as a dietary supplement ingredient, an unresolved and evolving regulatory question distinct from safety per se. Clinical trials to date have generally reported these precursors as well-tolerated over the trial durations studied, but long-term safety data in diverse populations remain limited.
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Where it's sold for research
We haven't built a dedicated vendor-availability page for NAD+ (Nicotinamide Adenine Dinucleotide) Precursors yet. See our full research-peptide vendor rankings →
NAD+ (Nicotinamide Adenine Dinucleotide) Precursors FAQ
Are NMN and NR the same as NAD+?+
No. NAD+ itself is not efficiently absorbed when taken orally; NMN and NR are precursor molecules that the body converts into NAD+, and most human research focuses on these precursors rather than NAD+ directly.
Is NMN FDA-approved?+
No. NMN has no FDA approval as a drug, and its regulatory status as a dietary supplement ingredient has been contested by the FDA due to its earlier investigational new drug status. This is a distinct, unresolved regulatory question, not a safety approval.
What does recent human research show about NMN vs. NR?+
A recent head-to-head human trial found both NMN and NR raised circulating NAD+ levels by a similar magnitude (roughly doubling it) over 14 days, while plain nicotinamide did not sustain the increase, with gut bacteria implicated in the conversion process.
Has NAD+ precursor supplementation been shown to reverse aging or extend human lifespan?+
No robust human evidence supports lifespan extension claims; the human research base focuses on measurable biomarkers like circulating NAD+ levels and specific disease-related outcomes, and reviews describe evidence in areas like sarcopenia as still inconclusive.
Sources for this page (5)
- 1 https://iadns.onlinelibrary.wiley.com/doi/10.1002/fft2.511
- 2 https://www.nmn.com/news/scientists-unveil-results-from-human-trial-directly-comparing-three-nad-precursors
- 3 https://pmc.ncbi.nlm.nih.gov/articles/PMC12022230/
- 4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12579426/
- 5 https://sciexplor.com/articles/Geromedicine.2025.0008
Researched together
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