Compound research
KPV: Research Overview & Current Status
KPV is a Alpha-MSH-derived tripeptide / anti-inflammatory peptide fragment. Current research status: preclinical research. KPV has no FDA or EMA approval and, per current research, no completed human clinical trials have been identified. Roughly two dozen studies published between 2001 and 2025 have examined KPV exclusively in cell culture, animal models (IBD, dermatitis, bronchial inflammation), and delivery-system experiments.
Live vendor pricing
Showing 82 of 82 listings.
Alpha Peptides
Tracked$25.25 / 10mg($25.25 to 10mg)
Checked Jul 31, 2026
Check price at Alpha Peptides →Ignite Peptides
Tracked$30.00 / 10mg($30.00 to 10mg)
Checked Jun 12, 2026
Check price at Ignite Peptides →TrustedPeps
Tracked$30.00 / 10mg($30.00 to 10mg)
Checked Aug 1, 2026
Check price at TrustedPeps →Elytra Labs
Tracked$30.00 / 10mg($30.00 to 10mg)
Checked Aug 2, 2026
Check price at Elytra Labs →Durham Peptides
Tracked$32.81 / 10mg($32.81 to 10mg)
Checked Aug 7, 2026
Check price at Durham Peptides →Puratek Peptides
Tracked$34.95 / 10mg($34.95 to 10mg)
Checked Jul 31, 2026
Check price at Puratek Peptides →Qureshi Labs
Tracked$34.99 / 10mg($34.99 to 10mg)
Checked Jul 25, 2026
Check price at Qureshi Labs →NextGen Peptides
Tracked$35.00 / 10mg($35.00 to 10mg)
Checked Jul 24, 2026
Check price at NextGen Peptides →Anglo Peptides
Tracked$35.68 / 10mg($35.68 to 10mg)
Checked Jul 19, 2026
Check price at Anglo Peptides →Everest Peptides
Tracked$35.99 / 10mg($35.99 to 10mg)
Checked Jul 28, 2026
Check price at Everest Peptides →Peptide Giants
Tracked$38.49 / 10mg($38.49 to 10mg)
Checked Aug 1, 2026
Check price at Peptide Giants →Amino Club
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Aug 7, 2026
Check price at Amino Club →Olympex Solutions
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Apr 6, 2026
Check price at Olympex Solutions →Woosh Labs
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Jun 24, 2026
Check price at Woosh Labs →IDUN Peptides
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Jul 17, 2026
Check price at IDUN Peptides →Refined BioLabs
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Jul 30, 2026
Check price at Refined BioLabs →Purgo Labs
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Aug 1, 2026
Check price at Purgo Labs →RUO Market
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Aug 2, 2026
Check price at RUO Market →Rivn Peptides
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Aug 14, 2026
Check price at Rivn Peptides →Peptides For Less
Tracked$40.00 / 10mg($40.00 to 10mg)
Checked Aug 13, 2026
Check price at Peptides For Less →PeakForce Labs
Tracked$40.00 / 10mg($40.00 to 10mg)
Checked Aug 15, 2026
Check price at PeakForce Labs →Offline Peptides
Tracked$43.00 / 10mg($43.00 to 10mg)
Checked Jul 28, 2026
Check price at Offline Peptides →EZ Peptides
Tracked$44.00 / 10mg($44.00 to 10mg)
Checked Aug 13, 2026
Check price at EZ Peptides →Orbitrex Peptides
Tracked$44.99 / 10mg($44.99 to 10mg)
Checked Aug 3, 2026
Check price at Orbitrex Peptides →Axon Chems
Tracked$45.00 / 10mg($45.00 to 10mg)
Checked Jul 31, 2026
Check price at Axon Chems →VoidResearch
Tracked$45.00 / 10mg($45.00 to 10mg)
Checked Jul 30, 2026
Check price at VoidResearch →Purity Peptides
Tracked$46.29 / 10mg($46.29 to 10mg)
Checked Jul 16, 2026
Check price at Purity Peptides →RemedyX Labs
Tracked$49.00 / 10mg($49.00 to 10mg)
Checked Aug 1, 2026
Check price at RemedyX Labs →Arizen Bio Labs
Tracked$49.99 / 10mg($49.99 to 10mg)
Checked Jun 21, 2026
Check price at Arizen Bio Labs →Evo Labs Research
Tracked$49.99 / 10mg($49.99 to 10mg)
Checked Jun 22, 2026
Check price at Evo Labs Research →Global Aminos
Tracked$49.99 / 10mg($49.99 to 10mg)
Checked Jul 28, 2026
Check price at Global Aminos →Mile High Compounds
Tracked$49.99 / 10mg($49.99 to 10mg)
Checked Aug 3, 2026
Check price at Mile High Compounds →Liv Pure Wellness
Tracked$50.00 / 10mg($50.00 to 10mg)
Checked Apr 14, 2026
Check price at Liv Pure Wellness →Premier Research
Tracked$50.00 / 10mg($50.00 to 10mg)
Checked Jul 20, 2026
Check price at Premier Research →PeakForm Peptides
Tracked$50.00 / 10mg($50.00 to 10mg)
Checked Aug 1, 2026
Check price at PeakForm Peptides →Glacier Aminos
Tracked$51.99 / 10mg($51.99 to 10mg)
Checked Jul 31, 2026
Check price at Glacier Aminos →CertaPeptides
Tracked$53.53 / 10mg($53.53 to 10mg)
Checked Jun 27, 2026
Check price at CertaPeptides →Polar Peptides
Tracked$53.99 / 10mg($53.99 to 10mg)
Checked Apr 17, 2026
Check price at Polar Peptides →Enhanced Chem
Tracked$54.99 / 10mg($54.99 to 10mg)
Checked Aug 15, 2026
Check price at Enhanced Chem →Hydro Research
Tracked$55.00 / 10mg($55.00 to 10mg)
Checked Jun 5, 2026
Check price at Hydro Research →Optima Supply
Tracked$55.00 / 10mg($55.00 to 10mg)
Checked Aug 3, 2026
Check price at Optima Supply →Atomik Labz
Tracked$55.00 / 10mg($55.00 to 10mg)
Checked Aug 4, 2026
Check price at Atomik Labz →Modern Aminos
Tracked$58.00 / 10mg($58.00 to 10mg)
Checked May 14, 2026
Check price at Modern Aminos →Purity Peptides
Tracked$29.19 / 5mg($58.38 to 10mg)
Checked Jul 16, 2026
Check price at Purity Peptides →True Research Labs
Tracked$59.00 / 10mg($59.00 to 10mg)
Checked Aug 15, 2026
Check price at True Research Labs →Particle Peptides
Tracked$29.59 / 5mg($59.18 to 10mg)
Checked Jul 24, 2026
Check price at Particle Peptides →LA Peptides
Tracked$59.99 / 10mg($59.99 to 10mg)
Checked May 14, 2026
Check price at LA Peptides →Eternal Peptides
Tracked$59.99 / 10mg($59.99 to 10mg)
Checked Aug 2, 2026
Check price at Eternal Peptides →Evolve Peptides
Tracked$60.00 / 10mg($60.00 to 10mg)
Checked Apr 22, 2026
Check price at Evolve Peptides →Enhanced Chem
Tracked$31.99 / 5mg($63.98 to 10mg)
Checked Aug 15, 2026
Check price at Enhanced Chem →SKO Compounds
Tracked$64.99 / 10mg($64.99 to 10mg)
Checked Jul 23, 2026
Check price at SKO Compounds →Nationwide Peptides
Tracked$65.00 / 10mg($65.00 to 10mg)
Checked Aug 5, 2026
Check price at Nationwide Peptides →Eternal Peptides
Tracked$34.99 / 5mg($69.98 to 10mg)
Checked Aug 2, 2026
Check price at Eternal Peptides →Apex Peptide Supply
Tracked$69.99 / 10mg($69.99 to 10mg)
Checked May 14, 2026
Check price at Apex Peptide Supply →CertaPeptides
Tracked$35.87 / 5mg($71.74 to 10mg)
Checked Jun 27, 2026
Check price at CertaPeptides →Swift Peptides
Tracked$71.99 / 10mg($71.99 to 10mg)
Checked Aug 6, 2026
Check price at Swift Peptides →$73.95 / 10mg($73.95 to 10mg)
Checked Jul 31, 2026
Check price at Amino Vault →Pristine Aminos
Tracked$75.00 / 10mg($75.00 to 10mg)
Checked Aug 2, 2026
Check price at Pristine Aminos →Licensed Peptides
Tracked$76.99 / 10mg($76.99 to 10mg)
Checked Jun 4, 2026
Check price at Licensed Peptides →$79.99 / 10mg($79.99 to 10mg)
Checked Apr 16, 2026
Check price at Ascension Peptides →Arizen Bio Labs
Tracked$79.99 / 30mg($79.99 to 10mg)
Checked Jun 21, 2026
Check price at Arizen Bio Labs →Pepsynth Labs
Tracked$40.00 / 5mg($80.00 to 10mg)
Checked Aug 7, 2026
Check price at Pepsynth Labs →Perfect Peptides
Tracked$85.00 / 10mg($85.00 to 10mg)
Checked Jul 27, 2026
Check price at Perfect Peptides →UNYX Peptides
Tracked$89.99 / 10mg($89.99 to 10mg)
Checked Jul 31, 2026
Check price at UNYX Peptides →BioLongevity Labs
Tracked$99.97 / 10mg($99.97 to 10mg)
Checked Aug 2, 2026
Check price at BioLongevity Labs →PureBio Labs
Tracked$99.99 / 10mg($99.99 to 10mg)
Checked Aug 5, 2026
Check price at PureBio Labs →Nationwide Peptides
Tracked$50.00 / 5mg($100.00 to 10mg)
Checked Aug 5, 2026
Check price at Nationwide Peptides →LeoLab Rx
Tracked$105.00 / 10mg($105.00 to 10mg)
Checked Apr 6, 2026
Check price at LeoLab Rx →$38.00 / 4mg($114.00 to 10mg)
Checked Apr 16, 2026
Check price at Core Peptides →$39.00 / 4mg($117.00 to 10mg)
Checked May 14, 2026
Check price at Biotech Peptides →Noble Sciences
Tracked$39.00 / 2mg($195.00 to 10mg)
Checked Aug 1, 2026
Check price at Noble Sciences →Euno Labs Research
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Jul 25, 2026
Check price at Euno Labs Research →Vantyx Research
Tracked$50.00 / 10mg($50.00 to 10mg)
Checked Aug 15, 2026
Check price at Vantyx Research →Chameleon Peptides
Tracked$57.60 / 10mg($57.60 to 10mg)
Checked Jul 31, 2026
Check price at Chameleon Peptides →Chameleon Peptides
Tracked$36.90 / 5mg($73.80 to 10mg)
Checked Jul 31, 2026
Check price at Chameleon Peptides →NextGen Peptides
Tracked$260.00 / 100mg($260.00 to 10mg)
Checked Jul 24, 2026
Check price at NextGen Peptides →KPV price report
KPV currently costs as little as $25.25 to obtain 10mg, from Alpha Peptides. Across the 74 vendors we track, the typical cost to 10mg is $50.00, using each vendor's own cheapest listing. 71 of those vendors show current stock, and prices were checked through Aug 15, 2026.
- Lowest to 10mg
- $25.25
- Alpha Peptides
- Median to 10mg
- $50.00
- one offer per vendor
- Lowest package
- $25.25
- 10mg at Alpha Peptides
- Vendors tracked
- 74
- 71 in stock
Checked through Aug 15, 2026. Prices are aggregated from public vendor listings. Sources and data licensing are documented on our methodology page.
At a glance
- Category
- recovery
- Mechanism class
- Melanocortin (MC-1R/MC-4R) agonist
- Research phase
- Research / preclinical only
- NCAA status
- Not explicitly listed (catchall risk) — Alpha-MSH tripeptide fragment; not listed by NCAA or WADA, not a performance enhancer.
- WADA status
- Likely permitted (topical/non-hormonal) — verify current WADA list
Overview
KPV (Lysine-Proline-Valine) is the minimal C-terminal tripeptide fragment (positions 11-13) of alpha-melanocyte-stimulating hormone (alpha-MSH), first shown by Hiltz and Lipton in 1989 to retain anti-inflammatory activity independent of alpha-MSH's pigmentation effects and without activating melanocortin receptors.
Alpha-MSH-derived tripeptide / anti-inflammatory peptide fragment
Research timeline
1989
Hiltz and Lipton first identified the KPV tripeptide fragment as retaining autonomous anti-inflammatory activity independent of alpha-MSH's melanocortin receptor-mediated pigmentation effects.
Source →1980s-1990s
Broader research by Catania, Lipton, and colleagues at Weill Cornell established that alpha-MSH and its fragments reduce fever, suppress inflammation, and modulate immune cell activity beyond pigmentation.
Source →2000s
Preclinical studies began characterizing KPV's efficacy in animal models of inflammatory bowel disease, contact dermatitis, and bronchial inflammation.
Source →2000s-2010s
Mechanistic studies identified inhibition of IkB kinase, preservation of IkBalpha, and prevention of NF-kB nuclear translocation as key anti-inflammatory pathways, along with inflammasome modulation (reduced IL-1beta, IL-18).
Source →2010s-2020s
Oral bioavailability of KPV demonstrated in colitis animal models via PepT1 transporter-mediated cellular uptake, notable because most peptides are degraded in the digestive tract.
Source →2001-2025
Cumulative body of roughly two dozen published studies on KPV's anti-inflammatory mechanisms across gut, skin, and lung models, entirely preclinical.
Source →
Active & recent research
KPV in inflammatory bowel disease models
Oral bioavailability and anti-inflammatory efficacy via PepT1-mediated uptake and NF-kB pathway inhibition
KPV mechanism of NF-kB inhibition
IkB kinase inhibition and preservation of IkBalpha to block NF-kB nuclear translocation and downstream cytokine production (TNF-alpha, IL-6, IL-1beta)
KPV in dermatitis and bronchial inflammation models
Reduction of inflammatory cytokine production and immune cell activation in non-gut tissue models
Key findings
- Foundational 1989 research by Hiltz and Lipton established that KPV retains the anti-inflammatory activity of full-length alpha-MSH despite lacking the receptor-binding motif needed to activate known melanocortin receptors, suggesting a distinct, not-fully-characterized signaling mechanism.
- Preclinical mechanistic studies report that KPV inhibits NF-kB signaling via IkB kinase inhibition and modulates the inflammasome pathway (reducing IL-1beta and IL-18), providing a plausible molecular basis for its reported anti-inflammatory effects across multiple animal models.
- A notable and unusual property reported in animal colitis models is oral bioavailability. KPV reportedly retains efficacy when taken by mouth, which is atypical for peptides that are usually degraded in digestion.
- As of current research, no human clinical trials of KPV have been completed; every reported finding derives from cell culture or animal models, and reviewers explicitly caution about possible publication bias favoring positive preclinical results.
Safety & regulatory notes
KPV has no FDA or EMA approval and, per current research, has not been evaluated in any completed human clinical trial. There is no established human safety, dosing, or pharmacokinetic profile. All available efficacy and safety signals come from preclinical cell-culture and animal-model research.
We may earn a commission when readers buy through links on this page, at no extra cost to you. Commissions never affect a vendor's score. Every vendor is graded on the same public rubric built from published lab documentation, live catalog pricing, and community sentiment. How we score →
Where it's sold for research
We haven't built a dedicated vendor-availability page for KPV yet. See our full research-peptide vendor rankings →
KPV FAQ
Has KPV been tested in humans?+
No completed human clinical trials of KPV have been identified in current research; all available evidence comes from cell culture and animal models (inflammatory bowel disease, dermatitis, bronchial inflammation).
How does KPV reduce inflammation mechanistically?+
Preclinical studies report that KPV inhibits NF-kB signaling by blocking IkB kinase activity and modulates the inflammasome pathway, reducing production of inflammatory cytokines like TNF-alpha, IL-6, and IL-1beta, though researchers note the exact signaling mechanism remains incompletely characterized.
Is KPV related to alpha-MSH and does it share its pigmentation effects?+
KPV is the minimal C-terminal tripeptide fragment of alpha-MSH, but it lacks the receptor-binding motif needed to activate melanocortin receptors, so research indicates it does not produce alpha-MSH's pigmentation effects while apparently retaining much of its anti-inflammatory activity.
Is KPV FDA-approved?+
No. KPV is an investigational research compound with no FDA or EMA approval and no completed human trials to date.
Sources for this page (4)
Researched together
Related: all compound research overviews · full price index · research radar · full vendor rankings · methodology