Compound research
Epithalon: Research Overview & Current Status
Epithalon is a Synthetic tetrapeptide (pineal gland-derived research peptide). Current research status: preclinical research. Epithalon has no FDA or EMA approval. Human evidence is limited largely to older cohort/observational data on the related compound epithalamin (a distinct pineal extract, not the synthetic tetrapeptide) plus small non-Western clinical reports; robust, modern, independently replicated human trials of synthetic Epithalon specifically are lacking.
Live vendor pricing
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Puratek Peptides
Tracked$26.95 / 10mg($26.95 to 10mg)
Checked Jul 31, 2026
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Tracked$26.99 / 10mg($26.99 to 10mg)
Checked Apr 17, 2026
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Tracked$28.54 / 10mg($28.54 to 10mg)
Checked Jul 19, 2026
Check price at Anglo Peptides →Amino Club
Tracked$29.99 / 10mg($29.99 to 10mg)
Checked Aug 7, 2026
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Tracked$29.99 / 10mg($29.99 to 10mg)
Checked Jun 24, 2026
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Tracked$29.99 / 10mg($29.99 to 10mg)
Checked Jul 16, 2026
Check price at Averix Labs →IDUN Peptides
Tracked$29.99 / 10mg($29.99 to 10mg)
Checked Jul 17, 2026
Check price at IDUN Peptides →Olympex Solutions
Tracked$30.00 / 10mg($30.00 to 10mg)
Checked Apr 6, 2026
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Tracked$30.00 / 10mg($30.00 to 10mg)
Checked Jul 31, 2026
Check price at Chameleon Peptides →Premier Research
Tracked$30.00 / 10mg($30.00 to 10mg)
Checked Jul 20, 2026
Check price at Premier Research →Elite Edge Biotech
Tracked$30.00 / 10mg($30.00 to 10mg)
Checked Jul 28, 2026
Check price at Elite Edge Biotech →Offline Peptides
Tracked$32.00 / 10mg($32.00 to 10mg)
Checked Jul 28, 2026
Check price at Offline Peptides →Glacier Aminos
Tracked$32.99 / 10mg($32.99 to 10mg)
Checked Jul 31, 2026
Check price at Glacier Aminos →Peptide Giants
Tracked$32.99 / 10mg($32.99 to 10mg)
Checked Aug 1, 2026
Check price at Peptide Giants →Axon Chems
Tracked$35.00 / 10mg($35.00 to 10mg)
Checked Jul 31, 2026
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Tracked$35.00 / 10mg($35.00 to 10mg)
Checked Aug 1, 2026
Check price at PeakForm Peptides →Atomik Labz
Tracked$35.00 / 10mg($35.00 to 10mg)
Checked Aug 4, 2026
Check price at Atomik Labz →EZ Peptides
Tracked$38.00 / 10mg($38.00 to 10mg)
Checked Aug 13, 2026
Check price at EZ Peptides →Particle Peptides
Tracked$38.84 / 10mg($38.84 to 10mg)
Checked Jul 24, 2026
Check price at Particle Peptides →Noble Sciences
Tracked$39.00 / 10mg($39.00 to 10mg)
Checked Aug 1, 2026
Check price at Noble Sciences →Polar Peptides
Tracked$39.59 / 10mg($39.59 to 10mg)
Checked Apr 17, 2026
Check price at Polar Peptides →Apex Peptide Supply
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked May 14, 2026
Check price at Apex Peptide Supply →Evo Labs Research
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Jun 22, 2026
Check price at Evo Labs Research →PeakForce Labs
Tracked$40.00 / 10mg($40.00 to 10mg)
Checked Aug 15, 2026
Check price at PeakForce Labs →Modern Aminos
Tracked$44.00 / 10mg($44.00 to 10mg)
Checked May 14, 2026
Check price at Modern Aminos →Pinnacle Peptide Labs
Tracked$44.99 / 10mg($44.99 to 10mg)
Checked Jul 22, 2026
Check price at Pinnacle Peptide Labs →Optima Supply
Tracked$44.99 / 13mg($44.99 to 10mg)
Checked Aug 3, 2026
Check price at Optima Supply →Hydro Research
Tracked$45.00 / 10mg($45.00 to 10mg)
Checked Jun 5, 2026
Check price at Hydro Research →Durham Peptides
Tracked$47.08 / 10mg($47.08 to 10mg)
Checked Aug 7, 2026
Check price at Durham Peptides →$47.60 / 10mg($47.60 to 10mg)
Checked Jul 31, 2026
Check price at Amino Vault →Evolve Peptides
Tracked$25.00 / 5mg($50.00 to 10mg)
Checked Apr 22, 2026
Check price at Evolve Peptides →Nationwide Peptides
Tracked$50.00 / 10mg($50.00 to 10mg)
Checked Aug 5, 2026
Check price at Nationwide Peptides →Onyx Research
Tracked$55.00 / 10mg($55.00 to 10mg)
Checked Apr 6, 2026
Check price at Onyx Research →True Research Labs
Tracked$59.00 / 50mg($59.00 to 10mg)
Checked Aug 15, 2026
Check price at True Research Labs →$59.99 / 10mg($59.99 to 10mg)
Checked Aug 10, 2026
Check price at PS Peptides →Elite Edge Biotech
Tracked$60.00 / 50mg($60.00 to 10mg)
Checked Jul 28, 2026
Check price at Elite Edge Biotech →Purity Peptides
Tracked$64.09 / 10mg($64.09 to 10mg)
Checked Jul 16, 2026
Check price at Purity Peptides →Liv Pure Wellness
Tracked$65.00 / 20mg($65.00 to 10mg)
Checked Apr 14, 2026
Check price at Liv Pure Wellness →Pristine Aminos
Tracked$65.00 / 10mg($65.00 to 10mg)
Checked Aug 2, 2026
Check price at Pristine Aminos →$69.99 / 10mg($69.99 to 10mg)
Checked Apr 16, 2026
Check price at Ascension Peptides →Pepsynth Labs
Tracked$70.00 / 10mg($70.00 to 10mg)
Checked Aug 7, 2026
Check price at Pepsynth Labs →NextGen Peptides
Tracked$75.00 / 50mg($75.00 to 10mg)
Checked Jul 24, 2026
Check price at NextGen Peptides →LA Peptides
Tracked$79.99 / 50mg($79.99 to 10mg)
Checked May 14, 2026
Check price at LA Peptides →Everest Peptides
Tracked$79.99 / 50mg($79.99 to 10mg)
Checked Jul 28, 2026
Check price at Everest Peptides →PureBio Labs
Tracked$79.99 / 10mg($79.99 to 10mg)
Checked Aug 5, 2026
Check price at PureBio Labs →Apex Peptides Lab
Tracked$40.00 / 5mg($80.00 to 10mg)
Checked Aug 15, 2026
Check price at Apex Peptides Lab →Peptide Giants
Tracked$82.49 / 50mg($82.49 to 10mg)
Checked Aug 1, 2026
Check price at Peptide Giants →Perfect Peptides
Tracked$85.00 / 10mg($85.00 to 10mg)
Checked Jul 27, 2026
Check price at Perfect Peptides →$90.00 / 25mg($90.00 to 10mg)
Checked Apr 16, 2026
Check price at Core Peptides →Axon Chems
Tracked$90.00 / 50mg($90.00 to 10mg)
Checked Jul 31, 2026
Check price at Axon Chems →Licensed Peptides
Tracked$91.99 / 10mg($91.99 to 10mg)
Checked Jun 4, 2026
Check price at Licensed Peptides →$94.00 / 25mg($94.00 to 10mg)
Checked May 14, 2026
Check price at Biotech Peptides →BioLongevity Labs
Tracked$94.97 / 20mg($94.97 to 10mg)
Checked Aug 2, 2026
Check price at BioLongevity Labs →Swift Peptides
Tracked$98.99 / 50mg($98.99 to 10mg)
Checked Aug 6, 2026
Check price at Swift Peptides →Offline Peptides
Tracked$99.00 / 50mg($99.00 to 10mg)
Checked Jul 28, 2026
Check price at Offline Peptides →Apex Peptides Lab
Tracked$99.00 / 50mg($99.00 to 10mg)
Checked Aug 15, 2026
Check price at Apex Peptides Lab →Premier Research
Tracked$100.00 / 50mg($100.00 to 10mg)
Checked Jul 20, 2026
Check price at Premier Research →Nationwide Peptides
Tracked$120.00 / 50mg($120.00 to 10mg)
Checked Aug 5, 2026
Check price at Nationwide Peptides →Dynotides
Tracked$128.00 / 50mg($128.00 to 10mg)
Checked Jul 20, 2026
Check price at Dynotides →Atomik Labz
Tracked$129.00 / 50mg($129.00 to 10mg)
Checked Aug 4, 2026
Check price at Atomik Labz →$129.99 / 50mg($129.99 to 10mg)
Checked Aug 10, 2026
Check price at PS Peptides →Evolve Peptides
Tracked$130.00 / 50mg($130.00 to 10mg)
Checked Apr 22, 2026
Check price at Evolve Peptides →Polar Peptides
Tracked$143.99 / 50mg($143.99 to 10mg)
Checked Apr 17, 2026
Check price at Polar Peptides →BioPure Peptides
Tracked$149.99 / 50mg($149.99 to 10mg)
Checked Jul 27, 2026
Check price at BioPure Peptides →Licensed Peptides
Tracked$191.99 / 50mg($191.99 to 10mg)
Checked Jun 4, 2026
Check price at Licensed Peptides →Perfect Peptides
Tracked$195.00 / 50mg($195.00 to 10mg)
Checked Jul 27, 2026
Check price at Perfect Peptides →Alpha Peptides
Tracked$23.68 / 10mg($23.68 to 10mg)
Checked Jul 31, 2026
Check price at Alpha Peptides →CertaPeptides
Tracked$74.04 / 50mg($74.04 to 10mg)
Checked Jun 27, 2026
Check price at CertaPeptides →Chameleon Peptides
Tracked$113.40 / 50mg($113.40 to 10mg)
Checked Jul 31, 2026
Check price at Chameleon Peptides →Pristine Aminos
Tracked$150.00 / 50mg($150.00 to 10mg)
Checked Aug 2, 2026
Check price at Pristine Aminos →Epithalon price report
Epithalon currently costs as little as $23.68 to obtain 10mg, from Alpha Peptides. Across the 64 vendors we track, the typical cost to 10mg is $44.99, using each vendor's own cheapest listing. 62 of those vendors show current stock, and prices were checked through Aug 15, 2026.
- Lowest to 10mg
- $23.68
- Alpha Peptides
- Median to 10mg
- $44.99
- one offer per vendor
- Lowest package
- $25.00
- 5mg at Evolve Peptides
- Vendors tracked
- 64
- 62 in stock
Checked through Aug 15, 2026. Prices are aggregated from public vendor listings. Sources and data licensing are documented on our methodology page.
At a glance
- Category
- immune
- Mechanism class
- Antimicrobial peptide
- Research phase
- Research / preclinical only
- NCAA status
- Not explicitly listed (catchall risk) — Tetrapeptide telomerase activator (Russian research); not on NCAA or WADA prohibited list. Catchall risk low — no class fit.
- WADA status
- Prohibited (WADA S2 — Peptide Hormones, Growth Factors, Related Substances)
Overview
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide developed from research into epithalamin, a bovine pineal gland extract studied in Russian gerontology research led by Vladimir Khavinson. It is investigated primarily for effects on telomerase activity and cellular senescence markers.
Synthetic tetrapeptide (pineal gland-derived research peptide)
Research timeline
2003
Foundational in vitro study reported that Epithalon induced telomerase activity and telomere elongation in human somatic cells.
Source →2004
Follow-up study reported Epithalon allowed human fetal fibroblasts to exceed their normal Hayflick division limit by at least 10 additional divisions versus controls.
Source →2000s
Animal studies reported lifespan extension in flies and rats and reduced age-related chromosomal abnormalities in mice following Epitalon administration.
Source →2000s-2010s
Cohort/observational studies on the related compound epithalamin (pineal extract, distinct from synthetic Epithalon) reported associations with improved physiological markers in older populations across multi-year follow-up.
Source →2025
Cell-line study examined Epitalon in normal epithelial cells, fibroblasts, and breast cancer cell lines, reporting dose-dependent telomere elongation in normal cells via hTERT/telomerase upregulation, while cancer cells showed a different response pattern.
Source →
Active & recent research
Epitalon effects on telomerase and telomere length across normal vs. cancer cell lines
Comparing dose-dependent telomere elongation mechanisms (hTERT/telomerase upregulation vs. alternative lengthening) between normal and malignant cells
Pineal peptide preparations and geroprotection
Synthesizing decades of pineal-extract and synthetic-tetrapeptide research on aging biomarkers
Key findings
- A 2003 in vitro study reported that Epithalon induced telomerase activity and telomere elongation in human somatic cells. This is the foundational finding underpinning most subsequent interest in the peptide.
- A 2025 cell-line study reported dose-dependent telomere length extension in normal cells (via apparent hTERT/telomerase upregulation) but noted cancer cell lines appeared to rely on different, alternative telomere-lengthening mechanisms, an important distinction researchers flag for safety interpretation.
- Animal studies have reported lifespan extension in flies and rats, but these findings have not been confirmed in controlled human lifespan or healthspan trials.
- Reviews caution that human data are dominated by older, non-Western observational cohorts on a related pineal extract (epithalamin) rather than rigorous modern RCTs of the synthetic tetrapeptide itself, and that the two compounds should not be conflated.
Safety & regulatory notes
Epithalon is not FDA-approved and has no established human dosing or long-term safety data from controlled trials. Reviews explicitly flag that non-approved peptides like Epitalon lack long-term safety data and systematic clinical validation. Because telomerase activation is mechanistically linked to processes relevant to cancer biology, researchers highlight this as an area requiring careful further study rather than an established risk or benefit.
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Where it's sold for research
We haven't built a dedicated vendor-availability page for Epithalon yet. See our full research-peptide vendor rankings →
Epithalon FAQ
Has Epithalon been tested in human clinical trials?+
Robust, modern, independently replicated human clinical trials of the synthetic Epithalon tetrapeptide are lacking; most human-adjacent data come from older observational cohorts studying a related but distinct pineal extract (epithalamin).
What is the evidence for Epithalon and telomeres?+
The evidence is strongest at the cell-culture level, where a 2003 study and later work reported telomerase induction and telomere elongation in human somatic cells, supported by some animal lifespan data, but this has not been established in controlled human trials.
Is Epithalon approved by the FDA?+
No. Epithalon has no FDA or EMA approval for any indication and remains an investigational research compound.
Are Epithalon and epithalamin the same thing?+
No. Epithalamin is a bovine pineal gland extract studied in earlier Russian research, while Epithalon (Epitalon) is a synthetic tetrapeptide developed based on its amino acid composition; sources caution against conflating findings between the two.
Sources for this page (5)
- 1 https://pubmed.ncbi.nlm.nih.gov/12937682/
- 2 https://www.researchgate.net/publication/10598271_Epithalon_Peptide_Induces_Telomerase_Activity_and_Telomere_Elongation_in_Human_Somatic_Cells
- 3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943447/
- 4 https://www.gethealthspan.com/research/article/epitalon
- 5 https://meto.co/blog/epitalon-telomeres-aging-peptide
Researched together
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