Compound research
PT-141 (Bremelanotide): Research Overview & Current Status
PT-141 (Bremelanotide) is a Melanocortin receptor agonist (cyclic heptapeptide). Current research status: fda-approved. Bremelanotide was FDA-approved in June 2019 under the brand name Vyleesi (Cosette Pharmaceuticals) for acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women, administered as a 1.75 mg subcutaneous injection. FDA approval applies specifically to the Vyleesi finished product; compounded bremelanotide preparations and off-label uses (e.g., in men or postmenopausal women) are not FDA-approved.
Live vendor pricing
Showing 68 of 68 listings.
Alpha Peptides
Tracked$22.07 / 10mg($22.07 to 10mg)
Checked Jul 31, 2026
Check price at Alpha Peptides →Elite Edge Biotech
Tracked$28.00 / 10mg($28.00 to 10mg)
Checked Jul 28, 2026
Check price at Elite Edge Biotech →Amino Club
Tracked$29.99 / 10mg($29.99 to 10mg)
Checked Aug 7, 2026
Check price at Amino Club →Woosh Labs
Tracked$29.99 / 10mg($29.99 to 10mg)
Checked Jun 24, 2026
Check price at Woosh Labs →Averix Labs
Tracked$29.99 / 10mg($29.99 to 10mg)
Checked Jul 16, 2026
Check price at Averix Labs →VoidResearch
Tracked$29.99 / 10mg($29.99 to 10mg)
Checked Jul 30, 2026
Check price at VoidResearch →Purgo Labs
Tracked$29.99 / 10mg($29.99 to 10mg)
Checked Aug 1, 2026
Check price at Purgo Labs →Pure Amino
Tracked$29.99 / 10mg($29.99 to 10mg)
Checked Aug 15, 2026
Check price at Pure Amino →Ignite Peptides
Tracked$30.00 / 10mg($30.00 to 10mg)
Checked Jun 12, 2026
Check price at Ignite Peptides →Purus Peptides
Tracked$31.00 / 10mg($31.00 to 10mg)
Checked Aug 6, 2026
Check price at Purus Peptides →Puratek Peptides
Tracked$31.45 / 10mg($31.45 to 10mg)
Checked Jul 31, 2026
Check price at Puratek Peptides →Peptide Giants
Tracked$32.99 / 10mg($32.99 to 10mg)
Checked Aug 1, 2026
Check price at Peptide Giants →Rivn Peptides
Tracked$32.99 / 10mg($32.99 to 10mg)
Checked Aug 14, 2026
Check price at Rivn Peptides →IDUN Peptides
Tracked$34.99 / 10mg($34.99 to 10mg)
Checked Jul 17, 2026
Check price at IDUN Peptides →RUO Market
Tracked$34.99 / 10mg($34.99 to 10mg)
Checked Aug 2, 2026
Check price at RUO Market →Badger Compounds
Tracked$34.99 / 10mg($34.99 to 10mg)
Checked Aug 15, 2026
Check price at Badger Compounds →Anglo Peptides
Tracked$35.68 / 10mg($35.68 to 10mg)
Checked Jul 19, 2026
Check price at Anglo Peptides →Everest Peptides
Tracked$35.99 / 10mg($35.99 to 10mg)
Checked Jul 28, 2026
Check price at Everest Peptides →GMR Peptides
Tracked$35.99 / 10mg($35.99 to 10mg)
Checked Jul 29, 2026
Check price at GMR Peptides →Offline Peptides
Tracked$37.00 / 10mg($37.00 to 10mg)
Checked Jul 28, 2026
Check price at Offline Peptides →Atomik Labz
Tracked$37.00 / 10mg($37.00 to 10mg)
Checked Aug 4, 2026
Check price at Atomik Labz →Chameleon Peptides
Tracked$37.80 / 10mg($37.80 to 10mg)
Checked Jul 31, 2026
Check price at Chameleon Peptides →Premier Research
Tracked$38.00 / 10mg($38.00 to 10mg)
Checked Jul 20, 2026
Check price at Premier Research →RemedyX Labs
Tracked$39.00 / 10mg($39.00 to 10mg)
Checked Aug 1, 2026
Check price at RemedyX Labs →Optimum Formula
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked May 14, 2026
Check price at Optimum Formula →Evo Labs Research
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Jun 22, 2026
Check price at Evo Labs Research →Orbitrex Peptides
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Aug 3, 2026
Check price at Orbitrex Peptides →PeakForm Peptides
Tracked$40.00 / 10mg($40.00 to 10mg)
Checked Aug 1, 2026
Check price at PeakForm Peptides →Glacier Aminos
Tracked$40.99 / 10mg($40.99 to 10mg)
Checked Jul 31, 2026
Check price at Glacier Aminos →Liv Pure Wellness
Tracked$42.99 / 10mg($42.99 to 10mg)
Checked Apr 14, 2026
Check price at Liv Pure Wellness →$43.00 / 10mg($43.00 to 10mg)
Checked Apr 16, 2026
Check price at Core Peptides →Modern Aminos
Tracked$44.00 / 10mg($44.00 to 10mg)
Checked May 14, 2026
Check price at Modern Aminos →Mile High Compounds
Tracked$44.99 / 10mg($44.99 to 10mg)
Checked Aug 3, 2026
Check price at Mile High Compounds →Evolve Peptides
Tracked$45.00 / 10mg($45.00 to 10mg)
Checked Apr 22, 2026
Check price at Evolve Peptides →Refined BioLabs
Tracked$45.00 / 10mg($45.00 to 10mg)
Checked Jul 30, 2026
Check price at Refined BioLabs →Apex Peptides
Tracked$45.00 / 10mg($45.00 to 10mg)
Checked Jul 31, 2026
Check price at Apex Peptides →PeakForce Labs
Tracked$45.00 / 10mg($45.00 to 10mg)
Checked Aug 15, 2026
Check price at PeakForce Labs →GLP-1 Research Lab
Tracked$46.00 / 10mg($46.00 to 10mg)
Checked Jun 19, 2026
Check price at GLP-1 Research Lab →Durham Peptides
Tracked$46.36 / 10mg($46.36 to 10mg)
Checked Aug 7, 2026
Check price at Durham Peptides →Amino Science Labs
Tracked$46.99 / 10mg($46.99 to 10mg)
Checked Jul 27, 2026
Check price at Amino Science Labs →CertaPeptides
Tracked$47.84 / 10mg($47.84 to 10mg)
Checked Jun 27, 2026
Check price at CertaPeptides →True Research Labs
Tracked$49.00 / 10mg($49.00 to 10mg)
Checked Aug 15, 2026
Check price at True Research Labs →$50.00 / 10mg($50.00 to 10mg)
Checked Apr 16, 2026
Check price at Ascension Peptides →Hydro Research
Tracked$50.00 / 10mg($50.00 to 10mg)
Checked Jun 5, 2026
Check price at Hydro Research →Optima Supply
Tracked$50.00 / 10mg($50.00 to 10mg)
Checked Aug 3, 2026
Check price at Optima Supply →Novatherix Laboratories
Tracked$54.99 / 10mg($54.99 to 10mg)
Checked Jun 4, 2026
Check price at Novatherix Laboratories →Swift Peptides
Tracked$54.99 / 10mg($54.99 to 10mg)
Checked Aug 6, 2026
Check price at Swift Peptides →Purity Peptides
Tracked$58.75 / 10mg($58.75 to 10mg)
Checked Jul 16, 2026
Check price at Purity Peptides →Nationwide Peptides
Tracked$59.00 / 10mg($59.00 to 10mg)
Checked Aug 5, 2026
Check price at Nationwide Peptides →Eternal Peptides
Tracked$59.99 / 10mg($59.99 to 10mg)
Checked Aug 2, 2026
Check price at Eternal Peptides →$61.00 / 10mg($61.00 to 10mg)
Checked Jul 31, 2026
Check price at Amino Vault →BioPure Peptides
Tracked$64.99 / 10mg($64.99 to 10mg)
Checked Jul 27, 2026
Check price at BioPure Peptides →Pristine Aminos
Tracked$65.00 / 10mg($65.00 to 10mg)
Checked Aug 2, 2026
Check price at Pristine Aminos →Apex Peptides Lab
Tracked$69.00 / 10mg($69.00 to 10mg)
Checked Aug 15, 2026
Check price at Apex Peptides Lab →SKO Compounds
Tracked$69.99 / 10mg($69.99 to 10mg)
Checked Jul 23, 2026
Check price at SKO Compounds →UNYX Peptides
Tracked$74.99 / 10mg($74.99 to 10mg)
Checked Jul 31, 2026
Check price at UNYX Peptides →Perfect Peptides
Tracked$75.00 / 10mg($75.00 to 10mg)
Checked Jul 27, 2026
Check price at Perfect Peptides →Licensed Peptides
Tracked$87.99 / 10mg($87.99 to 10mg)
Checked Jun 4, 2026
Check price at Licensed Peptides →BioLongevity Labs
Tracked$47.97 / 5mg($95.94 to 10mg)
Checked Aug 2, 2026
Check price at BioLongevity Labs →PureBio Labs
Tracked$99.99 / 10mg($99.99 to 10mg)
Checked Aug 5, 2026
Check price at PureBio Labs →NextGen Peptides
Tracked$24.99 / 10mg($24.99 to 10mg)
Checked Jul 24, 2026
Check price at NextGen Peptides →PT-141 (Bremelanotide) price report
PT-141 (Bremelanotide) currently costs as little as $22.07 to obtain 10mg, from Alpha Peptides. Across the 68 vendors we track, the typical cost to 10mg is $43.00, using each vendor's own cheapest listing. 66 of those vendors show current stock, and prices were checked through Aug 15, 2026.
- Lowest to 10mg
- $22.07
- Alpha Peptides
- Median to 10mg
- $43.00
- one offer per vendor
- Lowest package
- $22.07
- 10mg at Alpha Peptides
- Vendors tracked
- 68
- 66 in stock
Checked through Aug 15, 2026. Prices are aggregated from public vendor listings. Sources and data licensing are documented on our methodology page.
At a glance
- Category
- sexual health
- Mechanism class
- Melanocortin (MC-1R/MC-4R) agonist
- Research phase
- FDA approved (for specific indications)
- NCAA status
- Not explicitly listed (catchall risk) — FDA-approved melanocortin agonist (hypoactive sexual desire). Not explicitly listed by NCAA/WADA; catchall application is disputed but not enforced.
- WADA status
- Prohibited (WADA S2 — Peptide Hormones, Growth Factors, Related Substances)
Overview
PT-141, known generically as bremelanotide, is a synthetic cyclic heptapeptide that acts as an agonist at melanocortin MC3 and MC4 receptors in the central nervous system. Unlike PDE5-inhibitor erectile dysfunction drugs that act on peripheral blood flow, bremelanotide acts centrally on brain pathways implicated in sexual desire.
Melanocortin receptor agonist (cyclic heptapeptide)
Research timeline
1990s-2000s
Bremelanotide (PT-141) developed as a melanocortin receptor agonist, with earlier intranasal formulation studied in Phase 2 trials for sexual dysfunction.
Source →Phase 2
Intranasal PT-141 studied in Phase 2 trials but never advanced to Phase 3 or approval due to formulation/tolerability issues.
Source →2010s
Subcutaneous autoinjector formulation developed and advanced into the Phase 3 RECONNECT clinical trial program in premenopausal women with HSDD.
Source →2019 (pre-approval)
Two Phase 3 RECONNECT trials (~1,200 premenopausal women) met co-primary endpoints for improved sexual desire and reduced HSDD-related distress; FSFI desire domain effect sizes ranged 0.49-0.61.
Source →2019
FDA approved bremelanotide (Vyleesi) for acquired, generalized HSDD in premenopausal women. It was the first centrally-acting, non-hormonal peptide therapy approved for this indication.
Source →2019
A 52-week open-label extension safety study (Simon 2019) reported a consistent long-term safety profile.
Source →
Active & recent research
RECONNECT Phase 3 program
Efficacy and safety of subcutaneous bremelanotide for HSDD in premenopausal women
52-week open-label extension safety study
Long-term tolerability and adverse event profile with continued use
Off-label study of bremelanotide in men with PDE5-inhibitor-nonresponsive erectile dysfunction
Response rates in men who did not respond to PDE5 inhibitors, reported as exploratory/off-label rather than an approved indication
Key findings
- Two Phase 3 RECONNECT trials enrolling roughly 1,200 premenopausal women reported statistically significant improvements in sexual desire (FSFI desire domain) and reduced HSDD-related distress, forming the basis of FDA approval.
- A 52-week open-label extension study reported a consistent long-term safety profile, supporting continued-use tolerability beyond the initial 24-week trial period.
- The most commonly reported adverse effects across trials were nausea (up to ~40% with the first dose, diminishing with continued use), flushing, injection-site reactions, and headache, along with a transient rise in blood pressure and decrease in heart rate post-dose.
- Exploratory, off-label research in men with PDE5-inhibitor-nonresponsive erectile dysfunction reported higher response rates than placebo in small studies, but this is explicitly an off-label, non-FDA-approved use.
Safety & regulatory notes
Vyleesi (bremelanotide) is FDA-approved specifically for premenopausal women with acquired, generalized HSDD; it is not recommended for those with uncontrolled hypertension or cardiovascular disease due to transient blood pressure increases observed after dosing. Use in men or postmenopausal women, and use of compounded (non-Vyleesi) bremelanotide preparations, is off-label and outside the FDA-approved indication.
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Where it's sold for research
We haven't built a dedicated vendor-availability page for PT-141 (Bremelanotide) yet. See our full research-peptide vendor rankings →
PT-141 (Bremelanotide) FAQ
Is PT-141 FDA-approved?+
Yes, as bremelanotide under the brand name Vyleesi, FDA-approved in 2019 specifically for acquired, generalized hypoactive sexual desire disorder in premenopausal women. This approval does not extend to compounded preparations or other populations.
What clinical trials supported bremelanotide's approval?+
The Phase 3 RECONNECT trial program, involving about 1,200 premenopausal women, found bremelanotide met co-primary endpoints for improved sexual desire and reduced related distress compared with placebo.
What are the most commonly reported side effects?+
Trial data report nausea as the most common side effect (especially with the first dose), along with flushing, injection-site reactions, headache, and a transient increase in blood pressure with decreased heart rate after dosing.
Has bremelanotide been studied in men?+
Yes, in smaller off-label studies, particularly in men who did not respond to PDE5 inhibitors, but this use is not an FDA-approved indication and is considered investigational/off-label.
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