Compound research
MOTS-c: Research Overview & Current Status
MOTS-c is a Mitochondrial-derived peptide (MDP). Current research status: preclinical research. As of current search results, no completed or registered human clinical trials of MOTS-c or MOTS-c analogs were identified; the evidence base is exclusively cell-culture and animal-model research to date.
Live vendor pricing
Showing 160 of 160 listings.
Alpha Peptides
Tracked$27.55 / 10mg($27.55 to 10mg)
Checked Jul 31, 2026
Check price at Alpha Peptides →Anglo Peptides
Tracked$27.82 / 10mg($27.82 to 10mg)
Checked Jul 19, 2026
Check price at Anglo Peptides →Puratek Peptides
Tracked$29.95 / 10mg($29.95 to 10mg)
Checked Jul 31, 2026
Check price at Puratek Peptides →TrustedPeps
Tracked$30.00 / 10mg($30.00 to 10mg)
Checked Aug 1, 2026
Check price at TrustedPeps →Cielo Peptides
Tracked$30.00 / 10mg($30.00 to 10mg)
Checked Aug 8, 2026
Check price at Cielo Peptides →Endura Peptides
Tracked$33.00 / 10mg($33.00 to 10mg)
Checked Aug 3, 2026
Check price at Endura Peptides →Hydro Research
Tracked$35.00 / 10mg($35.00 to 10mg)
Checked Jun 5, 2026
Check price at Hydro Research →Ascending Labs
Tracked$35.00 / 10mg($35.00 to 10mg)
Checked Jul 25, 2026
Check price at Ascending Labs →Axiom Peptides
Tracked$37.00 / 10mg($37.00 to 10mg)
Checked Apr 14, 2026
Check price at Axiom Peptides →Refined BioLabs
Tracked$37.99 / 10mg($37.99 to 10mg)
Checked Jul 30, 2026
Check price at Refined BioLabs →Noble Sciences
Tracked$39.00 / 10mg($39.00 to 10mg)
Checked Aug 1, 2026
Check price at Noble Sciences →Durham Peptides
Tracked$39.23 / 10mg($39.23 to 10mg)
Checked Aug 7, 2026
Check price at Durham Peptides →Amino Club
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Aug 7, 2026
Check price at Amino Club →Woosh Labs
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Jun 24, 2026
Check price at Woosh Labs →IDUN Peptides
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Jul 17, 2026
Check price at IDUN Peptides →Euno Labs Research
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Jul 25, 2026
Check price at Euno Labs Research →Qureshi Labs
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Jul 25, 2026
Check price at Qureshi Labs →Everest Peptides
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Jul 28, 2026
Check price at Everest Peptides →VoidResearch
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Jul 30, 2026
Check price at VoidResearch →Pure Amino
Tracked$39.99 / 10mg($39.99 to 10mg)
Checked Aug 15, 2026
Check price at Pure Amino →Axon Chems
Tracked$40.00 / 10mg($40.00 to 10mg)
Checked Jul 31, 2026
Check price at Axon Chems →Purus Peptides
Tracked$40.00 / 10mg($40.00 to 10mg)
Checked Aug 6, 2026
Check price at Purus Peptides →Badger Compounds
Tracked$41.99 / 10mg($41.99 to 10mg)
Checked Aug 15, 2026
Check price at Badger Compounds →Purity Peptides
Tracked$42.72 / 10mg($42.72 to 10mg)
Checked Jul 16, 2026
Check price at Purity Peptides →Offline Peptides
Tracked$43.00 / 10mg($43.00 to 10mg)
Checked Jul 28, 2026
Check price at Offline Peptides →Olympex Solutions
Tracked$44.99 / 10mg($44.99 to 10mg)
Checked Apr 6, 2026
Check price at Olympex Solutions →Optimum Formula
Tracked$44.99 / 10mg($44.99 to 10mg)
Checked May 14, 2026
Check price at Optimum Formula →Midwest Peptide
Tracked$44.99 / 10mg($44.99 to 10mg)
Checked Jun 18, 2026
Check price at Midwest Peptide →Averix Labs
Tracked$44.99 / 10mg($44.99 to 10mg)
Checked Jul 16, 2026
Check price at Averix Labs →GMR Peptides
Tracked$44.99 / 10mg($44.99 to 10mg)
Checked Jul 29, 2026
Check price at GMR Peptides →RUO Market
Tracked$44.99 / 10mg($44.99 to 10mg)
Checked Aug 2, 2026
Check price at RUO Market →Premier Research
Tracked$45.00 / 10mg($45.00 to 10mg)
Checked Jul 20, 2026
Check price at Premier Research →Ascend Amino
Tracked$45.00 / 10mg($45.00 to 10mg)
Checked Jul 28, 2026
Check price at Ascend Amino →RemedyX Labs
Tracked$45.00 / 10mg($45.00 to 10mg)
Checked Aug 1, 2026
Check price at RemedyX Labs →Atomik Labz
Tracked$45.00 / 10mg($45.00 to 10mg)
Checked Aug 4, 2026
Check price at Atomik Labz →Peptides For Less
Tracked$45.00 / 10mg($45.00 to 10mg)
Checked Aug 13, 2026
Check price at Peptides For Less →Liv Pure Wellness
Tracked$45.99 / 10mg($45.99 to 10mg)
Checked Apr 14, 2026
Check price at Liv Pure Wellness →Glacier Aminos
Tracked$45.99 / 10mg($45.99 to 10mg)
Checked Jul 31, 2026
Check price at Glacier Aminos →GLP-1 Research Lab
Tracked$46.00 / 10mg($46.00 to 10mg)
Checked Jun 19, 2026
Check price at GLP-1 Research Lab →Polar Peptides
Tracked$46.79 / 10mg($46.79 to 10mg)
Checked Apr 17, 2026
Check price at Polar Peptides →CertaPeptides
Tracked$47.84 / 10mg($47.84 to 10mg)
Checked Jun 27, 2026
Check price at CertaPeptides →Rivn Peptides
Tracked$47.99 / 10mg($47.99 to 10mg)
Checked Aug 14, 2026
Check price at Rivn Peptides →Ignite Peptides
Tracked$48.00 / 10mg($48.00 to 10mg)
Checked Jun 12, 2026
Check price at Ignite Peptides →Pulse Peptides
Tracked$48.59 / 10mg($48.59 to 10mg)
Checked Apr 17, 2026
Check price at Pulse Peptides →Chameleon Peptides
Tracked$48.60 / 10mg($48.60 to 10mg)
Checked Jul 31, 2026
Check price at Chameleon Peptides →PeakForce Labs
Tracked$49.00 / 10mg($49.00 to 10mg)
Checked Aug 15, 2026
Check price at PeakForce Labs →Apex Peptide Supply
Tracked$49.99 / 10mg($49.99 to 10mg)
Checked May 14, 2026
Check price at Apex Peptide Supply →Arizen Bio Labs
Tracked$49.99 / 10mg($49.99 to 10mg)
Checked Jun 21, 2026
Check price at Arizen Bio Labs →Evo Labs Research
Tracked$49.99 / 10mg($49.99 to 10mg)
Checked Jun 22, 2026
Check price at Evo Labs Research →Elite Edge Biotech
Tracked$49.99 / 10mg($49.99 to 10mg)
Checked Jul 28, 2026
Check price at Elite Edge Biotech →Purgo Labs
Tracked$49.99 / 10mg($49.99 to 10mg)
Checked Aug 1, 2026
Check price at Purgo Labs →Orbitrex Peptides
Tracked$49.99 / 10mg($49.99 to 10mg)
Checked Aug 3, 2026
Check price at Orbitrex Peptides →Mile High Compounds
Tracked$49.99 / 10mg($49.99 to 10mg)
Checked Aug 3, 2026
Check price at Mile High Compounds →Enhanced Chem
Tracked$49.99 / 10mg($49.99 to 10mg)
Checked Aug 15, 2026
Check price at Enhanced Chem →Amino Science Labs
Tracked$51.99 / 10mg($51.99 to 10mg)
Checked Jul 27, 2026
Check price at Amino Science Labs →EZ Peptides
Tracked$54.00 / 10mg($54.00 to 10mg)
Checked Aug 13, 2026
Check price at EZ Peptides →Global Aminos
Tracked$54.99 / 10mg($54.99 to 10mg)
Checked Jul 28, 2026
Check price at Global Aminos →Pantheon Peptides
Tracked$56.16 / 10mg($56.16 to 10mg)
Checked Apr 23, 2026
Check price at Pantheon Peptides →Peptide Giants
Tracked$57.74 / 10mg($57.74 to 10mg)
Checked Aug 1, 2026
Check price at Peptide Giants →Modern Aminos
Tracked$58.00 / 10mg($58.00 to 10mg)
Checked May 14, 2026
Check price at Modern Aminos →True Research Labs
Tracked$59.00 / 10mg($59.00 to 10mg)
Checked Aug 15, 2026
Check price at True Research Labs →$59.49 / 10mg($59.49 to 10mg)
Checked Jul 31, 2026
Check price at Amino Vault →Novatherix Laboratories
Tracked$59.99 / 10mg($59.99 to 10mg)
Checked Jun 4, 2026
Check price at Novatherix Laboratories →Eternal Peptides
Tracked$59.99 / 10mg($59.99 to 10mg)
Checked Aug 2, 2026
Check price at Eternal Peptides →$60.00 / 10mg($60.00 to 10mg)
Checked Apr 16, 2026
Check price at Ascension Peptides →Evolve Peptides
Tracked$60.00 / 10mg($60.00 to 10mg)
Checked Apr 22, 2026
Check price at Evolve Peptides →UNYX Peptides
Tracked$60.00 / 10mg($60.00 to 10mg)
Checked Jul 31, 2026
Check price at UNYX Peptides →PeakForm Peptides
Tracked$60.00 / 10mg($60.00 to 10mg)
Checked Aug 1, 2026
Check price at PeakForm Peptides →Pristine Aminos
Tracked$60.00 / 10mg($60.00 to 10mg)
Checked Aug 2, 2026
Check price at Pristine Aminos →Optima Supply
Tracked$65.00 / 10mg($65.00 to 10mg)
Checked Aug 3, 2026
Check price at Optima Supply →Elytra Labs
Tracked$65.00 / 40mg($65.00 to 10mg)
Checked Aug 2, 2026
Check price at Elytra Labs →Nationwide Peptides
Tracked$65.00 / 10mg($65.00 to 10mg)
Checked Aug 5, 2026
Check price at Nationwide Peptides →Puratek Peptides
Tracked$69.95 / 40mg($69.95 to 10mg)
Checked Jul 31, 2026
Check price at Puratek Peptides →LA Peptides
Tracked$69.99 / 10mg($69.99 to 10mg)
Checked May 14, 2026
Check price at LA Peptides →BioPure Peptides
Tracked$69.99 / 10mg($69.99 to 10mg)
Checked Jul 27, 2026
Check price at BioPure Peptides →$69.99 / 10mg($69.99 to 10mg)
Checked Aug 10, 2026
Check price at PS Peptides →Purity Peptides
Tracked$71.21 / 20mg($71.21 to 10mg)
Checked Jul 16, 2026
Check price at Purity Peptides →Onyx Research
Tracked$75.00 / 10mg($75.00 to 10mg)
Checked Apr 6, 2026
Check price at Onyx Research →Red River Peptides
Tracked$75.00 / 40mg($75.00 to 10mg)
Checked May 19, 2026
Check price at Red River Peptides →Premier Research
Tracked$75.00 / 20mg($75.00 to 10mg)
Checked Jul 20, 2026
Check price at Premier Research →Licensed Peptides
Tracked$76.99 / 10mg($76.99 to 10mg)
Checked Jun 4, 2026
Check price at Licensed Peptides →Nationwide Peptides
Tracked$77.00 / 20mg($77.00 to 10mg)
Checked Aug 5, 2026
Check price at Nationwide Peptides →Endura Peptides
Tracked$78.00 / 40mg($78.00 to 10mg)
Checked Aug 3, 2026
Check price at Endura Peptides →Apex Peptides Lab
Tracked$79.00 / 10mg($79.00 to 10mg)
Checked Aug 15, 2026
Check price at Apex Peptides Lab →Glacier Aminos
Tracked$79.99 / 20mg($79.99 to 10mg)
Checked Jul 31, 2026
Check price at Glacier Aminos →SKO Compounds
Tracked$79.99 / 10mg($79.99 to 10mg)
Checked Jul 23, 2026
Check price at SKO Compounds →Qureshi Labs
Tracked$79.99 / 20mg($79.99 to 10mg)
Checked Jul 25, 2026
Check price at Qureshi Labs →NextGen Peptides
Tracked$80.00 / 40mg($80.00 to 10mg)
Checked Jul 24, 2026
Check price at NextGen Peptides →Chameleon Peptides
Tracked$81.90 / 20mg($81.90 to 10mg)
Checked Jul 31, 2026
Check price at Chameleon Peptides →Badger Compounds
Tracked$83.99 / 40mg($83.99 to 10mg)
Checked Aug 15, 2026
Check price at Badger Compounds →Perfect Peptides
Tracked$89.00 / 20mg($89.00 to 10mg)
Checked Jul 27, 2026
Check price at Perfect Peptides →Pepsynth Labs
Tracked$89.60 / 10mg($89.60 to 10mg)
Checked Aug 7, 2026
Check price at Pepsynth Labs →Offline Peptides
Tracked$92.00 / 40mg($92.00 to 10mg)
Checked Jul 28, 2026
Check price at Offline Peptides →$99.00 / 10mg($99.00 to 10mg)
Checked May 14, 2026
Check price at Biotech Peptides →Atomik Labz
Tracked$99.00 / 40mg($99.00 to 10mg)
Checked Aug 4, 2026
Check price at Atomik Labz →Rivn Peptides
Tracked$99.99 / 40mg($99.99 to 10mg)
Checked Aug 14, 2026
Check price at Rivn Peptides →Axon Chems
Tracked$100.00 / 40mg($100.00 to 10mg)
Checked Jul 31, 2026
Check price at Axon Chems →Nationwide Peptides
Tracked$100.00 / 30mg($100.00 to 10mg)
Checked Aug 5, 2026
Check price at Nationwide Peptides →Peptides For Less
Tracked$100.00 / 40mg($100.00 to 10mg)
Checked Aug 13, 2026
Check price at Peptides For Less →LeoLab Rx
Tracked$105.00 / 10mg($105.00 to 10mg)
Checked Apr 6, 2026
Check price at LeoLab Rx →Purus Peptides
Tracked$105.00 / 40mg($105.00 to 10mg)
Checked Aug 6, 2026
Check price at Purus Peptides →Apex Peptides Lab
Tracked$109.00 / 40mg($109.00 to 10mg)
Checked Aug 15, 2026
Check price at Apex Peptides Lab →BioLongevity Labs
Tracked$109.97 / 10mg($109.97 to 10mg)
Checked Aug 2, 2026
Check price at BioLongevity Labs →Arizen Bio Labs
Tracked$109.99 / 30mg($109.99 to 10mg)
Checked Jun 21, 2026
Check price at Arizen Bio Labs →Evo Labs Research
Tracked$109.99 / 40mg($109.99 to 10mg)
Checked Jun 22, 2026
Check price at Evo Labs Research →PureBio Labs
Tracked$109.99 / 10mg($109.99 to 10mg)
Checked Aug 5, 2026
Check price at PureBio Labs →Swift Peptides
Tracked$109.99 / 40mg($109.99 to 10mg)
Checked Aug 6, 2026
Check price at Swift Peptides →Everest Peptides
Tracked$111.99 / 40mg($111.99 to 10mg)
Checked Jul 28, 2026
Check price at Everest Peptides →Purity Peptides
Tracked$113.94 / 40mg($113.94 to 10mg)
Checked Jul 16, 2026
Check price at Purity Peptides →$116.00 / 10mg($116.00 to 10mg)
Checked Apr 16, 2026
Check price at Core Peptides →CertaPeptides
Tracked$117.90 / 40mg($117.90 to 10mg)
Checked Jun 27, 2026
Check price at CertaPeptides →Arizen Bio Labs
Tracked$119.99 / 40mg($119.99 to 10mg)
Checked Jun 21, 2026
Check price at Arizen Bio Labs →Liv Pure Wellness
Tracked$120.00 / 40mg($120.00 to 10mg)
Checked Apr 14, 2026
Check price at Liv Pure Wellness →Durham Peptides
Tracked$121.27 / 40mg($121.27 to 10mg)
Checked Aug 7, 2026
Check price at Durham Peptides →Purgo Labs
Tracked$124.99 / 40mg($124.99 to 10mg)
Checked Aug 1, 2026
Check price at Purgo Labs →Elite Edge Biotech
Tracked$125.00 / 40mg($125.00 to 10mg)
Checked Jul 28, 2026
Check price at Elite Edge Biotech →True Research Labs
Tracked$129.00 / 40mg($129.00 to 10mg)
Checked Aug 15, 2026
Check price at True Research Labs →Refined BioLabs
Tracked$129.99 / 40mg($129.99 to 10mg)
Checked Jul 30, 2026
Check price at Refined BioLabs →Chameleon Peptides
Tracked$134.10 / 40mg($134.10 to 10mg)
Checked Jul 31, 2026
Check price at Chameleon Peptides →Woosh Labs
Tracked$135.00 / 40mg($135.00 to 10mg)
Checked Jun 24, 2026
Check price at Woosh Labs →Dynotides
Tracked$138.00 / 40mg($138.00 to 10mg)
Checked Jul 20, 2026
Check price at Dynotides →Novatherix Laboratories
Tracked$139.99 / 40mg($139.99 to 10mg)
Checked Jun 4, 2026
Check price at Novatherix Laboratories →Mile High Compounds
Tracked$139.99 / 40mg($139.99 to 10mg)
Checked Aug 3, 2026
Check price at Mile High Compounds →NeuroLabs
Tracked$140.00 / 40mg($140.00 to 10mg)
Checked Jul 31, 2026
Check price at NeuroLabs →Polar Peptides
Tracked$143.99 / 40mg($143.99 to 10mg)
Checked Apr 17, 2026
Check price at Polar Peptides →Peptide Giants
Tracked$148.49 / 40mg($148.49 to 10mg)
Checked Aug 1, 2026
Check price at Peptide Giants →Qureshi Labs
Tracked$149.99 / 40mg($149.99 to 10mg)
Checked Jul 25, 2026
Check price at Qureshi Labs →Amino Science Labs
Tracked$149.99 / 40mg($149.99 to 10mg)
Checked Jul 27, 2026
Check price at Amino Science Labs →Orbitrex Peptides
Tracked$149.99 / 40mg($149.99 to 10mg)
Checked Aug 3, 2026
Check price at Orbitrex Peptides →PeakForce Labs
Tracked$150.00 / 40mg($150.00 to 10mg)
Checked Aug 15, 2026
Check price at PeakForce Labs →Apex Peptides
Tracked$160.00 / 40mg($160.00 to 10mg)
Checked Jul 31, 2026
Check price at Apex Peptides →Pepsynth Labs
Tracked$164.00 / 20mg($164.00 to 10mg)
Checked Aug 7, 2026
Check price at Pepsynth Labs →Licensed Peptides
Tracked$169.99 / 40mg($169.99 to 10mg)
Checked Jun 4, 2026
Check price at Licensed Peptides →Perfect Peptides
Tracked$175.00 / 40mg($175.00 to 10mg)
Checked Jul 27, 2026
Check price at Perfect Peptides →Nationwide Peptides
Tracked$176.00 / 40mg($176.00 to 10mg)
Checked Aug 5, 2026
Check price at Nationwide Peptides →UNYX Peptides
Tracked$189.99 / 40mg($189.99 to 10mg)
Checked Jul 31, 2026
Check price at UNYX Peptides →$189.99 / 50mg($189.99 to 10mg)
Checked Aug 10, 2026
Check price at PS Peptides →$203.15 / 40mg($203.15 to 10mg)
Checked Jul 31, 2026
Check price at Amino Vault →Pepsynth Labs
Tracked$280.00 / 40mg($280.00 to 10mg)
Checked Aug 7, 2026
Check price at Pepsynth Labs →Particle Peptides
Tracked$36.99 / 10mg($36.99 to 10mg)
Checked Jul 24, 2026
Check price at Particle Peptides →Vantyx Research
Tracked$80.00 / 40mg($80.00 to 10mg)
Checked Aug 15, 2026
Check price at Vantyx Research →Pristine Aminos
Tracked$85.00 / 20mg($85.00 to 10mg)
Checked Aug 2, 2026
Check price at Pristine Aminos →Peptide Giants
Tracked$87.99 / 20mg($87.99 to 10mg)
Checked Aug 1, 2026
Check price at Peptide Giants →Pristine Aminos
Tracked$150.00 / 50mg($150.00 to 10mg)
Checked Aug 2, 2026
Check price at Pristine Aminos →MOTS-c price report
MOTS-c currently costs as little as $27.55 to obtain 10mg, from Alpha Peptides. Across the 107 vendors we track, the typical cost to 10mg is $49.99, using each vendor's own cheapest listing. 104 of those vendors show current stock, and prices were checked through Aug 15, 2026.
- Lowest to 10mg
- $27.55
- Alpha Peptides
- Median to 10mg
- $49.99
- one offer per vendor
- Lowest package
- $27.55
- 10mg at Alpha Peptides
- Vendors tracked
- 107
- 104 in stock
Checked through Aug 15, 2026. Prices are aggregated from public vendor listings. Sources and data licensing are documented on our methodology page.
At a glance
- Category
- longevity
- Mechanism class
- Mitochondrial / longevity peptide
- Research phase
- Research / preclinical only
- NCAA status
- Banned (NCAA 2025-26 list) — Mitochondrial-derived peptide and AMPK activator / exercise mimetic; banned under NCAA catchall (same mechanism class as AICAR in WADA S4.4).
- WADA status
- Prohibited (WADA S2 — Peptide Hormones, Growth Factors, Related Substances)
Overview
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene region rather than nuclear DNA, distinguishing it from most regulatory peptides. Under metabolic stress it translocates to the nucleus and influences expression of nuclear genes involved in metabolic homeostasis, and its mechanism is centrally linked to AMPK pathway activation.
Mitochondrial-derived peptide (MDP)
Research timeline
2015
Early review discussed MOTS-c as a candidate 'longevity' mitochondrial-derived peptide, including association of an MOTS-c-region mtDNA polymorphism with longevity in a Northeast Asian population.
Source →2021
Study reported MOTS-c improves glucose metabolism in skeletal muscle and increases with exercise in humans, positioning it as an exercise-responsive metabolic regulator.
Source →2021
In vitro study on aged human placenta-derived mesenchymal stem cells reported MOTS-c improved mitochondrial homeostasis via AMPK activation and mTORC1 inhibition.
Source →2023
Review article summarized MOTS-c's therapeutic potential across metabolic disease, inflammation, and aging models.
Source →2023
Mouse study reported MOTS-c reduced neuropathic pain behavior via AMPK-mediated inhibition of microglial activation and oxidative damage after spared nerve injury.
Source →
Active & recent research
MOTS-c effects on mitochondrial homeostasis in aged mesenchymal stem cells
AMPK activation and mTORC1 inhibition as a mechanism for restoring youthful mitochondrial function
MOTS-c in neuropathic pain
Reduction of microglial activation and spinal oxidative damage via AMPK pathway
MOTS-c and soft tissue/flap survival
Lysosomal membrane stabilization, angiogenesis, and collagen remodeling in transplanted tissue
MOTS-c and skeletal muscle bioenergetics
PGC-1a/AMPK-dependent improvement of intrinsic muscle mitochondrial efficiency
Key findings
- A 2023 review in a peer-reviewed journal characterized MOTS-c as a 'promising' mitochondrial-derived peptide across metabolic, inflammatory, and aging research models, while noting its exploratory stage.
- A 2021 study reported that exercise increases MOTS-c levels in human skeletal muscle and circulation, suggesting it functions as an exercise-responsive signaling peptide, though this reflects endogenous physiology rather than exogenous administration outcomes.
- Animal and cell studies have consistently implicated AMPK activation and mTORC1 inhibition as the core mechanism behind MOTS-c's reported effects on glucose metabolism, inflammation, and cellular aging markers.
- No human clinical trials of exogenously administered MOTS-c have been identified in current research; all reported benefits come from preclinical (cell culture and animal) models and should be interpreted accordingly.
Safety & regulatory notes
MOTS-c has no FDA approval and, per current research, has not entered registered human clinical trials as an administered therapeutic. There is no established human safety or pharmacokinetic profile for exogenous MOTS-c administration; all available data are preclinical.
We may earn a commission when readers buy through links on this page, at no extra cost to you. Commissions never affect a vendor's score. Every vendor is graded on the same public rubric built from published lab documentation, live catalog pricing, and community sentiment. How we score →
Where it's sold for research
We haven't built a dedicated vendor-availability page for MOTS-c yet. See our full research-peptide vendor rankings →
MOTS-c FAQ
Has MOTS-c been tested in humans?+
Endogenous MOTS-c levels have been measured in human blood and muscle (e.g., in exercise studies), but no completed clinical trials evaluating exogenously administered MOTS-c in humans have been identified in current research.
What is MOTS-c's proposed mechanism?+
Research models point to activation of AMPK and inhibition of mTORC1 signaling as the primary pathway through which MOTS-c is reported to influence metabolic and mitochondrial function in cell and animal studies.
Is MOTS-c approved for any medical use?+
No. MOTS-c has no FDA approval or approved medical indication anywhere; it remains an investigational research compound studied only in preclinical models.
What conditions has MOTS-c been studied in?+
Preclinical studies have explored MOTS-c in models of metabolic dysfunction, aging cell homeostasis, neuropathic pain, and tissue/flap survival, but all in animal or cell-culture settings, not human trials.
Sources for this page (7)
- 1 https://pubmed.ncbi.nlm.nih.gov/36761202/
- 2 https://pubmed.ncbi.nlm.nih.gov/33639272/
- 3 https://pubmed.ncbi.nlm.nih.gov/37285113/
- 4 https://pubmed.ncbi.nlm.nih.gov/42153537/
- 5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905433/
- 6 https://pubmed.ncbi.nlm.nih.gov/41520850/
- 7 https://pubmed.ncbi.nlm.nih.gov/26289118/
Researched together
Related: all compound research overviews · full price index · research radar · full vendor rankings · methodology