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Compound research

AOD-9604: Research Overview & Current Status

Discontinued in clinical development

AOD-9604 is a Growth hormone fragment peptide (hGH 176-191 modified fragment). Current research status: discontinued in clinical development. AOD-9604 completed six human clinical trials (over 900 participants) for obesity between 2001-2007 but development was discontinued in 2007 after a Phase IIb trial failed to show statistically significant weight loss versus placebo. It has never received FDA, EMA, or TGA approval for any indication, and in December 2024 the FDA determined AOD-9604 should not be included on the 503A Bulks List for compounding, citing limited long-term safety data and immunogenicity concerns.

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Particle Peptides

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Peptide Giants

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Puratek Peptides

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Everest Peptides

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Hydro Research

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Evolve Peptides

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Polar Peptides

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$43.19 / 5mg($86.38 to 10mg)

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True Research Labs

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Promino

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SKO Compounds

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Onyx Research

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PeakForm Peptides

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Liv Pure Wellness

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Apex Peptides

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CertaPeptides

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$45.56 / 5mg($91.12 to 10mg)

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Durham Peptides

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$46.36 / 5mg($92.72 to 10mg)

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Glacier Aminos

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$92.99 / 10mg($92.99 to 10mg)

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Purus Peptides

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$49.00 / 5mg($98.00 to 10mg)

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Peptide Giants

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$49.49 / 5mg($98.98 to 10mg)

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Swift Peptides

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$98.99 / 10mg($98.99 to 10mg)

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Amino Club

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RUO Market

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LeoLab Rx

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NeuroLabs

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Nationwide Peptides

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Modern Aminos

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$54.00 / 5mg($108.00 to 10mg)

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CertaPeptides

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$108.21 / 10mg($108.21 to 10mg)

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Peptide Giants

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Swift Peptides

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Evolve Peptides

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$55.00 / 5mg($110.00 to 10mg)

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Optima Supply

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$55.00 / 5mg($110.00 to 10mg)

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PeakForce Labs

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$55.00 / 5mg($110.00 to 10mg)

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Liv Pure Wellness

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$59.99 / 5mg($119.98 to 10mg)

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Orbitrex Peptides

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Mile High Compounds

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Evolve Peptides

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$135.00 / 20mg($135.00 to 10mg)

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Apex Peptides Lab

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$69.00 / 5mg($138.00 to 10mg)

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Nationwide Peptides

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$145.00 / 10mg($145.00 to 10mg)

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Dynotides

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$32.40 / 2mg($162.00 to 10mg)

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EZ Peptides

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PureBio Labs

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Hydro Research

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Alpha Peptides

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Alpha Peptides

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Pepsynth Labs

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$80.00 / 10mg($80.00 to 10mg)

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Purity Peptides

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$49.85 / 5mg($99.70 to 10mg)

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Rivn Peptides

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$53.00 / 5mg($106.00 to 10mg)

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$200.00 / 50mg($200.00 to 10mg)

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AOD-9604 price report

AOD-9604 currently costs as little as $40.00 to obtain 10mg, from Cielo Peptides. Across the 58 vendors we track, the typical cost to 10mg is $90.00, using each vendor's own cheapest listing. 55 of those vendors show current stock, and prices were checked through Aug 15, 2026.

Lowest to 10mg
$40.00
Cielo Peptides
Median to 10mg
$90.00
one offer per vendor
Lowest package
$21.99
2mg at Peptide Giants
Vendors tracked
58
55 in stock

Checked through Aug 15, 2026. Prices are aggregated from public vendor listings. Sources and data licensing are documented on our methodology page.

At a glance

Category
fat loss
Mechanism class
IGF-1 / MGF analog
Research phase
Research / preclinical only
NCAA status
Banned (NCAA 2025-26 list) — Modified hGH fragment 177-191; banned under NCAA growth hormone entry / WADA S2.1 GH and releasing factors.
WADA status
Prohibited (WADA S2 — Peptide Hormones, Growth Factors, Related Substances)

Overview

AOD-9604 is a modified fragment of the C-terminal region (amino acids 176-191) of human growth hormone, engineered by Metabolic Pharmaceuticals Ltd. in Australia in the 1990s to isolate GH's lipolytic (fat-metabolizing) activity while removing its broader growth-promoting and metabolic effects.

Growth hormone fragment peptide (hGH 176-191 modified fragment)

Research timeline

  1. 1990s

    AOD-9604 developed by Metabolic Pharmaceuticals Ltd. (Australia) as a modified hGH fragment isolating lipolytic activity.

    Source →
  2. 2001-2007

    Metabolic Pharmaceuticals conducted six human clinical trials involving over 900 participants evaluating AOD-9604 for obesity management.

    Source →
  3. circa 2005

    Phase IIa trial (12 weeks, 300 participants) reported modest weight reduction of 2.6 kg versus 0.8 kg for placebo.

    Source →
  4. 2007

    Phase IIb trial (24 weeks, 536 subjects) found no statistically significant weight-loss difference versus placebo, leading Metabolic Pharmaceuticals to terminate obesity-indication development.

    Source →
  5. Post-2007

    AOD-9604 was licensed for exploration in osteoarthritis research, pivoting away from the obesity indication.

    Source →
  6. 2024

    FDA determined AOD-9604 should not be added to the 503A Bulks List for compounding pharmacies, citing limited long-term safety data, peptide impurities, and immunogenicity concerns.

    Source →
  7. 2026

    As of April 2026, AOD-9604 is listed as 'Nominated but Withdrawn' from FDA Category 2 nomination status.

    Source →

Active & recent research

Phase IIb, completed 2007

AOD-9604 Phase IIb obesity trial (completed, negative result)

Weight-loss efficacy versus placebo over 24 weeks in 536 subjects; did not reach statistical significance

Post-2007 licensing/exploratory

AOD-9604 in osteoarthritis research

Investigating a pivot indication after the obesity trial program was discontinued

Key findings

  • A 12-week Phase IIa trial (300 participants) reported a modest but statistically distinguishable weight reduction (2.6 kg vs. 0.8 kg placebo), which supported advancement to Phase IIb.
  • The subsequent 24-week Phase IIb trial (536 subjects), the largest and most rigorous trial conducted, found no statistically significant difference in weight loss versus placebo, which led directly to program termination in 2007.
  • Across all six completed trials (900+ participants), AOD-9604 was reported as well-tolerated with minimal adverse effects; the program failure was attributed to efficacy, not safety.
  • The FDA's December 2024 determination against including AOD-9604 on the 503A Bulks List reflects ongoing regulatory concern about limited long-term human safety data even outside the original obesity indication.

Safety & regulatory notes

AOD-9604 is not FDA-approved for any indication. Its formal obesity development program was discontinued in 2007 due to lack of efficacy in the pivotal Phase IIb trial, not due to safety findings. The trials reported it as well-tolerated. However, in December 2024 the FDA declined to add AOD-9604 to the 503A Bulks List used by compounding pharmacies, citing limited long-term safety data, peptide impurity concerns, and potential immunogenicity, and its FDA Category 2 nomination was subsequently withdrawn.

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Where it's sold for research

We haven't built a dedicated vendor-availability page for AOD-9604 yet. See our full research-peptide vendor rankings →

AOD-9604 FAQ

Is AOD-9604 FDA-approved for weight loss?+

No. AOD-9604 was never approved by the FDA, EMA, or TGA. Its obesity clinical development program was discontinued in 2007 after a Phase IIb trial failed to show statistically significant weight loss versus placebo.

Why was AOD-9604 development discontinued?+

Development ended for efficacy reasons, not safety: the pivotal Phase IIb trial (536 subjects, 24 weeks) found no statistically significant weight-loss benefit at the tested dose compared with placebo.

Was AOD-9604 considered safe in its trials?+

Across six completed trials with over 900 participants, AOD-9604 was reported as well-tolerated with minimal adverse effects; the program's failure was attributed specifically to lack of efficacy.

What is AOD-9604's current regulatory status?+

As of the FDA's December 2024 determination, AOD-9604 is not included on the 503A Bulks List for pharmaceutical compounding, and its FDA Category 2 nomination has been withdrawn, reflecting ongoing regulatory caution about limited long-term safety data.

Sources for this page (3)

  1. 1 https://emiratitimes.com/lessons-from-a-discontinued-aod-9604-research-peptide/
  2. 2 https://www.perxpeptides.com/blog/is-aod-9604-fda-approved
  3. 3 https://peptidepedia.org/weight-loss/aod-9604

Researched together

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